It can cause abnormal eye movements, weakness, unsteadiness and seizures. *Caused by Dirofilaria immitis. An infected mosquito bites your dog, infecting your dog with heartworm larvae. * ProHeart 12 is for use in healthy dogs 12 months of age and older. See the basics about heartworm disease, including your dog’s risk and some of the signs and symptoms. Do not administer to dogs that are sick, debilitated, underweight, have a history of weight loss, or to those previously found to be hypersensitive to the drug. It has also been used off label to treat adult heartworms. Talk with your veterinarian about ProHeart 12 for your dog. Arguably the scariest drug side effect that a pet parent can witness is anaphylaxis – a potentially fatal type of allergic reaction. Electrocution: First Aid. Moxidectin topical is applied to the skin and is commonly used to prevent heartworms and to treat topical and intestinal parasites. Steroids (prednisone, prednisolone, dexamethasone, etc.) Yes. The product information provided in this site is intended only for residents of the United States. In fact, in a clinical study with client-owned dogs, ProHeart 12 had a similar adverse event profile to Heartgard Plus. Store at temperatures below 30°C (86°F). AHS Canine Guidelines 2020. https://d3ft8sckhnqim2.cloudfront.net/images/pdf/2020_AHS_Canine_Guidelines.pdf?1580934824, accessed 1/27/21. Exercise increases the risk of embolism, thereby increasing the risk of serious side effects or death. Side effects Localized side effects. Usually washing the area with mild soap and cool water and some time is all that is needed to for the skin to return to normal, then avoid using the product that caused the reaction in the future. What’s the difference between ProHeart 6 and ProHeart 12? This often resolves over time as the body adjusts to the medication or if the drug is given with a meal, but sometimes more serious symptoms do develop. *From an infected mosquito. The commonly prescribed antibiotic metronidazole is also known to have an effect on the brain, especially at high doses or in elderly patients. The reaction develops quickly, often within just a few minutes to a half hour or so after the pet has been given the medication. Ask your veterinarian about the benefits of adding ProHeart 12 to your annual wellness visit. Volume 6C Summary of the Product Characteristics: SPC – Pharmaceuticals. All rights reserved. https://ec.europa.eu/health/sites/health/files/files/eudralex/vol-6/c/spcpharmaceuticals_10-07-2006_en.pdf, accessed 2/1/21. Zoetis Inc. European Commission 2006. The symptoms of anaphylaxis occur after a pet has been exposed to a medication at least a couple of times. This is the exact list of adverse events on the label … Unfortunately, some of these side effects are idiosyncratic, meaning that they don’t occur often and it’s impossible to determine beforehand which individuals are at risk. They are supplied as follows: NDC 42799-806-01 unit dose packages of 20. Following injection with ProHeart 6, peak moxidectin blood levels will be observed approximately 7-14 days after treatment. Talk with your veterinarian about switching to ProHeart 12 from another heartworm disease preventative. Probiotic supplements often help prevent or relieve antibiotic-associated diarrhea. Inc. ProHeart 6 Freedom of Information Summary: 2001/06/06 Original NADA 141-189. Certification is required before veterinarians and staff administer these products. Antibiotics are notorious for causing gastrointestinal signs, particularly diarrhea, because they can disrupt the bacterial population in the gut that is essential for normal digestion. It’s so important to keep your dog protected. (And, in case you missed it … there’s 3 times as much moxidectin in ProHeart 12 as Proheart 6 … so side effects are likely to be greater.) *ProHeart 12 is indicated for the treatment of existing larval and adult hookworm (Ancylostoma caninum and Uncinaria stenocephala) infections. Not sure when your dog last had a heartworm test? 01/14 ProHeart 12 can be used in healthy dogs 12 months of age and older. Preventing and Treating Pet Medication Side Effects, Top 10 Ways to Stop Your Cat from Peeing Outside the Litter Box, 10 Weird Cat Behaviors That Could Be Signs of a Sick Cat, 7 Ways Cat Lovers Can Celebrate International Cat Day. Reported side effects in clinical trials included vomiting, lethargy, diarrhea, anorexia, and hypersensitivity reactions. ... (TECA) for End-Stage Ears in Dogs and Cats. Was demonstrated to be safe for most types of dogs over 12 months, including: Collies sensitive to ivermectin—a common ingredient in monthly heartworm products, Had a similar adverse event profile to Heartgard® Plus. But owners can do a lot to protect their pets from the side effects of medications. The product label for ProHeart 12 cites an alarmingly long list of adverse events of ProHeart 6. No, ProHeart 12 is not a vaccine because it does not stimulate the production of antibodies. We’ve only covered some of the more common types of pet medication side effects here. Symptoms of toxicity include dilated pupils, unsteadiness, mental dullness, drooling, vomiting, blindness, tremors, seizures, coma and death. Just one dose of ProHeart 12 provides protection for your dog all year long. Dogs older than 6 months but less than 1 year old should be given ProHeart 6. TPLO (Tibial Plateau Leveling Osteotomy) in Dogs. How much does ProHeart 12 typically cost? Transporting an Injured Pet: First Aid. It works by slowly releasing microspheres of the antiparasitic drug, moxidectin, over the course of 12 months. Cost may vary depending on how much your dog weighs. Does my dog need a heartworm test before starting ProHeart 12? Anaphylactic and anaphylactoid reactions can result in death and should be treated immediately with the same measures used to treat hypersensitivity reactions to vaccines and other injectable products. Hypersensitivity reactions may occur in some dogs when PROHEART is administered alone or with vaccines. Please see full Prescribing Information for ProHeart 6. And finally, never change the dosage or dosing schedule of your pet’s medications without first talking to your vet. So, strict confinement is essential during the treatment period and for at least one month following the last injection of medicine. See full Prescribing Information for ProHeart 6 and ProHeart 12. Ask your veterinarian for details. Medications that decrease the production of stomach acid and protect the lining of the gastrointestinal tract can help heal and prevent ulcers. In some cases, the relationship is obvious. Reporting rates can underestimate the actual number of adverse events, due to under-reporting. These medications should never be given together (this greatly increases the risk of ulceration). A genetic test is available to identify at risk dogs. Take Our Quiz to Find Out if Your Dog’s Protected from Heartworm Disease, The Importance of Full-Year Heartworm Disease Protection for Your Dog, Take the Bite out of Mosquitoes and Heartworms. The ProHeart 12 injection works similarly to ProHeart 6, but instead of providing heartworm protection for six months, it will last a whole year. A good example is the relationship between nonsteroidal anti-inflammatories (NSAIDs) and liver failure in dogs. It could take longer than 7 months for the heartworms to be detectable with routine testing. First and foremost, talk to your veterinarian. Drug interactions increase the chances that side effects might develop. *Doses sold are calculated using standard dog weight of 44 lbs and provide an estimate of the number of dogs treated. https://d3ft8sckhnqim2.cloudfront.net/images/pdf/2020_AHS_Canine_Guidelines.pdf?1580934824, https://ec.europa.eu/health/sites/health/files/files/eudralex/vol-6/c/spcpharmaceuticals_10-07-2006_en.pdf. These usually disappear over the course of a few days to weeks, but if this does not occur, talk to your veterinarian. Purchase ProHeart and earn up to 200 points, Redeem your points to a reloadable Zoetis Petcare Rewards card, Use the card to help pay for any product or service at the vet. and nonsteroidal anti-inflammatory medications (carprofen, deracoxib and firocoxib to name a few) are known to increase a pet’s risk of developing gastrointestinal ulcers which can lead to vomiting and/or diarrhea that may contain blood. Side effects are uncommon but may include lethargy, vomiting, uncoordinated walking, anorexia, diarrhea, and itching. Other skin reactions are also possible, although they are quite rare. Zoetis knows moxidectin can be harmful to dogs. Effects Spay and Neuter Timing on Cancer in Dogs. What Are the Symptoms of Heartworm Disease in Dogs? ProHeart 6 Pharmacovigilance Data. ProHeart 6 is a twice-yearly dose to prevent heartworm disease in dogs, 20 million doses sold over a 10‑year period3, Demonstrated safe in special populations like:4, Dogs sensitive to ivermectin—a common ingredient in monthly products for heartworm disease, Many common medicines were given at the same time in clinical trials.

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